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. 2020 Sep 26;10(10):453. doi: 10.1007/s13205-020-02433-9

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© King Abdulaziz City for Science and Technology 2020, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — The miR-199a-5p expression levels in colorectal cancer (CRC) tissues and adjacent normal tissues. a Heat map of the differentially expressed miRNAs. The miRNA expression profiles in CRC tissues and adjacent normal tissues (n = 3) were identified by miRNA microarray analysis. Red or green color separately represents high or low expression. b miR-199a-5p level was significantly decreased in CRC tissues compared with that in adjacent normal tissues (n = 50) (**P < 0.01 vs. adjacent tissue group). c miR-199a-5p level was significantly decreased in CRC cell lines HT29, SW620, SW480, HCT116, compared with that in normal human colon mucosal epithelial cell line NCM460. (**P < 0.01 vs. NCM460 group)