Fig. 2.

Effects of miR-199a-5p on the cell proliferation and cleaved-caspase-3 level in CRC cells. The HTC116 and SW480 cells were transfected with miR-199a-5p mimics or mimics NC for 48 h, and then the cells were harvested for further experiments. a miR-199a-5p expression level in miR-199a-5p mimics group was significantly increased in HTC116 and SW480 cells compared with mimic NC group. b and c Cell proliferation of HTC116 and SW480 cells in miR-199a-5p mimics group was markedly reduced compared with mimic NC group. d The cleaved-caspase-3 protein expression in miR-199a-5p mimics group was significantly increased compared with mimic NC group. e The activity of caspase 3 in miR-199a-5p mimics group was significantly increased compared with mimic NC group. (*P < 0.05, **P < 0.01 vs. mimics NC)