Fig. 4.

Effects of silencing Caprin1 on the cell proliferation and apotosis in CRC cells. The HTC116 or SW480 cells were transfected with si-Caprin1 and NC si-RNA for 48 h. a Caprin1 mRNA level in si-Caprin1 group was significantly decreased compared with NC si-RNA group. b and c Cell proliferation of HTC116 and SW480 cells in si-Caprin1 group was markedly reduced compared with NC si-RNA group. d The cleaved-caspase-3 protein expression in si-Caprin1 group was significantly increased compared with NC si-RNA group. e The activity of caspase 3 in si-Caprin1 group was significantly increased compared with NC si-RNA group (*P < 0.05, **P < 0.01 vs. si-RNA)