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肺癌中铁死亡受抑相关研究进展
Research progress on ferroptotic suppression in lung cancer
| Researcher | Nationality | Related Pathway | Target | Conclusions/Results |
| SCLC: small cell lung cancer; NSCLC: non-small cell lung cancer; LPO: lipid peroxides; GPX4: glutathione peroxidase 4; NFS-1: iron-sulfur cluster biosynthetic enzyme; LSH: lymphoid-specific helicase; CBS: cystathionine-β-synthase. | ||||
| Huang Y[15] | USA | GSH synthesis pathway |
System Xc- | Over expression of SLC7A11 and SLC3A2 in lung cancer cells |
| Ji XM[16] | USA | System Xc- | Over expression of SLC7A11 in NSCLC cells | |
| Lai Y[17] | China | GPX4 | Over expression of GPX4 in NSCLC cells due to STYK1 | |
| Kukulj S[18] | Croatia | Iron metabolism pathway |
Ferritin | Reduced LIP due to over expression of ferritin |
| Ji M[19] | China | |||
| Alvarez SW[23] | USA | NSF-1 | Reduced LIP due to over expression of NSF-1 | |
| Jiang YQ[24] | China | Lipid synthesis pathway | LSH | Activation of lipid metablic and ferroptotic genes due to over expression of LSH |
| Bersuker K[25] | USA | FSP1 synthesis pathway | FSP1 | Halted propagation of LPO due to over expression of FSP1 with CRISPR-Cas9 screen |
| Doll S[26] | Germany | Halted propagation of LPO due to over expression of FSP1 with expression cloning approach | ||
| Wang M[27] | China | Epigenetic pathway | LSH | Over expression of transsulfuration marker CBS due to LSH |