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NCCN指南中对于其他相对少见基因变异型NSCLC患者推荐的靶向/免疫治疗方案(在我国相关药物适应证尚未获批)[5]
Appropriate treatment options for other molecular biomarker positive patients recommended by NCCN NSCLC guidelines[5]
| 生物标志物 | 推荐靶向/免疫治疗方案 |
| NCCN指南推荐证据等级，无特殊指明均为2A类推荐。 | |
| MET高水平扩增 | -克唑替尼 |
| MET 14号外显子跳跃突变 | - Capmatinib、克唑替尼 |
| RET重排 | - Selpercatinib、卡博替尼、Vandetanib |
| ERBB2(HER2)突变 | -曲妥珠单抗-美坦新偶联物(Ado-trastuzumab emtansine) |
| 高TMB | -纳武利尤单抗单药或联合Ipilimumab |
