Figure 4.

Effects of JTW on protein of A₁R (a), ERK1/2 (b), and c-Fos (c) expression in the prefrontal cortex. Mice were administered vehicle, JTW (3.3 and 6.6 mg/kg), or imipramine (10 mg/kg) once daily for 14 consecutive days. On the last day, mice were sacrificed after 30 min drug administration. Values are the mean ± S.E.M. with 6 mice in each group. Compared with vehicle-treated ovariectomized mice, ^#p < 0.05; compared with vehicle-treated ovariectomized mice subjected to chronic unpredictable stress, ^∗p < 0.05 and ^∗∗p < 0.01.