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. 2020 Mar 24;36(15):4291–4295. doi: 10.1093/bioinformatics/btaa198

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Gene relevance automatically detects drivers of embryonic blood development. (a) Diffusion map of 271 single hematopoietic progenitor cells from mostly Day 7.5 and 7.75 mouse embryos, profiled in Scialdone et al. (2016). (b) Global gene relevance identifies Hbb-bh1 and Hba-x as genes that change most dramatically during hematopoietic development. (c) A gene relevance map identifies the contribution of relevant genes in specific regions of the process and the corresponding code to create it. The genes corresponding to each color are shown in panel (b). (d) A local gene relevance plot details the areas where the contribution of genes is highest. Alox5ap shows a high local relevance in the top region of the diffusion map and has been implicated with early blood development Ibarra-Soria et al. (2018)