Table 4. Univariate and multivariate Cox regression analysis of overall survival in each cohort.

Variables	Univariate analysis				Multivariate analysis
	HR	HR.95L	HR.95H	P	HR	HR.95L	HR.95H	P
TCGA training cohort (n = 445)
Age(≥68/ <68)	0.999	0.98	1.018	0.922	1.007	0.987	1.028	0.491
Gender (female/male)	1.006	0.692	1.462	0.976	0.936	0.638	1.373	0.736
TNM stage (I+II/III+IV)	1.659	1.404	1.961	3.01E−09	2.677	0.994	2.831	0.043
T	1.592	1.278	1.982	3.27E−05	1.009	0.788	1.291	0.944
N	1.798	1.463	2.209	2.34E−08	1.142	0.714	1.826	0.58
M	1.798	0.985	3.283	0.056	0.466	0.116	1.871	0.281
Risk Score	3.89	2.925	5.174	9.79E−21	3.699	2.717	5.036	9.80E−17
GSE30219 testing cohort (n = 83)
Age(≥68/ <68)	1.037	1.023	1.052	3.22E−07	1.031	0.994	1.07	0.102
Gender(female/male)	1.815	1.129	2.917	0.014	1.126	0.491	2.586	0.779
TNM stage(I+II/III+IV)	2.719	0.762	3.03	2.35E−03	2.409	1.014	2.882	0.044
T	1.663	1.448	1.911	7.10E−13	1.361	1.126	1.644	0.001
N	1.777	1.51	2.091	4.36E−12	1.358	1.087	1.698	0.007
M	2.856	1.17	6.97	0.021	2.357	0.958	5.797	0.062
Risk Score	3.726	1.429	9.714	0.007	2.26	1.168	4.374	0.016
GSE72094 testing cohort (n = 393)
Age(≥68/<68)	1.007	0.988	1.027	0.479	0.999	0.978	1.019	0.889
Gender(female/male)	1.547	1.065	2.246	0.022	1.487	1.011	2.189	0.044
TNM stage	1.625	1.360	1.941	<0.001	1.607	1.333	1.938	<0.001
Risk Score	1.736	1.514	1.990	<0.001	1.646	1.431	1.894	<0.001

Notes.

HR

hazard ratio

TNM

tumornode metastasis