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. 2020 Sep 22;12:8773–8785. doi: 10.2147/CMAR.S260537

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© 2020 Liu et al.

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Knockdown of PVT1 expression suppresses CRC tumor growth in vivo. HCT116 cells, stably transfected with sh-PVT1 and sh-NC, were subcutaneously injected into nude mice to establish murine xenograft models. (A) Tumor volume was measured at 0 d, 7 d, 14 d, 21d, and 28 d after injection. (B) Tumor weight was detected in each group after killing the mouse. (C–F) The expression levels of PVT1, miR-106b-5p as well as FJX1 were measured in two groups by qRT-PCR or Western blot, respectively. *P<0.05.