Table 1.
Targeted CD47/SIRPα Antibody Research in Recent Years
| Year | Product | Ab | Diseases |
|---|---|---|---|
| 2015 | Hu 5F9-G4 | Anti‐CD47Ab(IgG4) | Solid tumors, non-Hodgkin’s lymphoma, acute myeloid leukemia, myelodysplastic syndrome |
| 2017 | CC‐90002 | Anti‐CD47Ab(IgG4) | Solid tumors, non-Hodgkin’s lymphoma, acute myeloid leukemia, myelodysplastic syndrome |
| TTI‐621 | SIRPα‐Fc(IgG1) | Solid tumors, acute myeloid leukemia | |
| 2018 | ALX148 | Anti-SIRPα(IgG1Fc) | Solid tumors, hematopoietic malignancies |
| 2019 | A0-176 | Anti‐CD47Ab(IgG4) | Solid tumors, hematopoietic malignancies |
| 2020 | HuNb1-IgG4 | Anti‐CD47Ab(IgG4) | Lymphoma, Ovarian cancer |