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. 2020 Sep 22;13:9323–9331. doi: 10.2147/OTT.S249822

Table 1.

Targeted CD47/SIRPα Antibody Research in Recent Years

Year Product Ab Diseases
2015 Hu 5F9-G4 Anti‐CD47Ab(IgG4) Solid tumors, non-Hodgkin’s lymphoma, acute myeloid leukemia, myelodysplastic syndrome
2017 CC‐90002 Anti‐CD47Ab(IgG4) Solid tumors, non-Hodgkin’s lymphoma, acute myeloid leukemia, myelodysplastic syndrome
TTI‐621 SIRPα‐Fc(IgG1) Solid tumors, acute myeloid leukemia
2018 ALX148 Anti-SIRPα(IgG1Fc) Solid tumors, hematopoietic malignancies
2019 A0-176 Anti‐CD47Ab(IgG4) Solid tumors, hematopoietic malignancies
2020 HuNb1-IgG4 Anti‐CD47Ab(IgG4) Lymphoma, Ovarian cancer