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. 2020 Sep 23;13:9389–9405. doi: 10.2147/OTT.S251965

Table 3.

Joint Effects Analysis of ALOXE3 and ALOX12 Expressions in COAD Patients OS

Group ALOXE3 ALOX12 Patients (n=438) No. of Event MST (days) Crude HR (95%CI) Crude P Adjusted HR (95%CI) Adjusted Pa
A Low Low 120 17 NA 1 0.003 1 0.027
B Low High 99 21 1849 1.873 (0.987–3.552) 0.055 1.263 (0.573–2.780) 0.563
C High Low 99 18 NA 1.396 (0.719–2.709) 0.325 1.324 (0.600–2.918) 0.487
D High High 120 42 1711 2.710 (1.542–4.765) 0.01 2.472 (1.248–4.900) 0.009

Notes: aAdjusted for gender, TNM stage, CEA, KRAS and lymphatic invasion.

Abbreviations: ALOX, lipoxygenases; OS, overall survival; MST, median survival time; TCGA, The Cancer Genome Atlas; NA, not available. CEA, carcino-embryonic antigen.