TABLE 4.
Multivariate OR, their 95% CI, and measures of interaction of combined two‐way exposures between tobacco smoking and alcohol drinking for HNSCC stratified by Hr‐HPV status
| Risk factor combinations | HPV‐Hr‐negative | HPV‐Hr‐positive | ||
|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | |
| Smoking and alcohol a | ||||
| Never smoker‐non drinker | 1 | Ref | 1 | Ref |
| Never smoker drinker | 3.09 | 1.03‐9.22 | 0.56 | 0.05‐6.72 |
| Ever smoker‐non drinker | 4.89 | 1.99‐12.03 | 1.41 | 0.27‐7.32 |
| Ever smoker‐drinker | 23.43 | 10.11‐54.30 | 3.57 | 0.88‐14.48 |
| Ψ (95% CI) | 1.55 | 0.43‐5.58 | 4.52 | 0.21‐97.84 |
| RERI (95% CI) | 16.45 | 1.76‐31.16 | 2.59 | −1.65 to 6.84 |
French West Indies, 2013‐2016.
Abbreviations: CI, confidence interval; HNSCC, head and neck squamous cell carcinomas; HPV, human papillomavirus; OR, odds ratio; RERI, relative excess risk due to interaction; Ψ, multiplicative interaction parameter.
a
Model adjusted for age, sex, recruitment site.