Table 1.
Genes differentially expressed in skeletal muscles following crush muscle injury. The table presents transcripts with a FR > |1.5| with P < .05 in I vs N‐I and I vs C. Bold fonts indicate genes differentially expressed both at 3 and 5 days
| Gene symbol | Gene description | 3 days | 5 days | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Paired I vs N‐I | I vs C | Paired I vs N‐I | I vs C | ||||||
| FR | P‐value | FR | P‐value | FR | P‐value | FR | P‐value | ||
| ECM molecules | |||||||||
| COL3A1 | Collagen Type III Alpha 1 Chain | 4.36 | .009 | 3.76 | .033 | ||||
| COL5A1 | Collagen Type V Alpha 1 Chain | 10.45 | .036 | ||||||
| COL6A1 | Collagen Type VI Alpha 1 Chain | 1.56 | .048 | ||||||
| ECM1 | Extracellular matrix protein 1 | 2.16 | .003 | ||||||
| FN1 | Fibronectin 1 | 4.93 | .036 | 7.97 | .025 | ||||
| SPOCK1 | SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 1 | −8.13 | .048 | ||||||
| Basement membrane molecules | |||||||||
| COL4A2 | Collagen Type IV Alpha 2 Chain | −1.87 | .0004 | ||||||
| LAMA2 | Laminin Subunit Alpha 2 | −3.64 | .024 | −1.92 | .005 | ||||
| LAMB2 | Laminin Subunit Beta 2 | −1.96 | .019 | −2.79 | .011 | ||||
| LAMC1 | Laminin Subunit Gamma 1 | −1.69 | .007 | −2.43 | .003 | ||||
| Cell‐to‐ECM Adhesion molecules | |||||||||
| ITGAL | Integrin Subunit Alpha L | 2.36 | .042 | ||||||
| ITGAM | Integrin Subunit Alpha M | 7.61 | .023 | 14.92 | .022 | ||||
| ITGAX | Integrin alpha X | 4.96 | .019 | 2.84 | .048 | ||||
| ITGB2 | Integrin Subunit Beta 2 | 5.26 | .047 | ||||||
| CD44 | CD44 Molecule | 8.06 | .015 | 4.83 | .050 | ||||
| ECM Proteases | |||||||||
| MMP8 | Matrix Metallopeptidase 8 | 16,491 | .037 | 4.919 | .038 | ||||
| MMP14 | Matrix Metallopeptidase 14 | 1.98 | .001 | ||||||
| ADAMTS2 | A disintegrin‐like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 | 1.96 | .004 | 3.16 | .039 | ||||
| MMP15 | Matrix Metallopeptidase 15 | −2.28 | .014 | ||||||
| Matricellular proteins for cell adhesion | |||||||||
| POSTN | Periostin, osteoblast‐specific factor | 43.39 | .032 | 16.15 | .027 | ||||
| THBS2 | Thrombospondin 2 | 3.31 | .050 | 6.17 | .027 | ||||
| THBS3 | Thrombospondin 3 | 2.4 | .005 | ||||||
| VCAN | Versican | 4.10 | .012 | 6.95 | .004 | 4.68 | .039 | 7.20 | .019 |
| VTN | Vitronectin | −5.16 | .041 | −4.49 | .028 | ||||
| Proteases inhibitors | |||||||||
| TIMP2 | TIMP Metallopeptidase Inhibitor 2 | 2.1 | .017 | ||||||
| TIMP1 | TIMP Metallopeptidase Inhibitor 1 | 5.04 | .00001 | ||||||
| TIMP3 | TIMP Metallopeptidase Inhibitor 3 | −4.27 | .010 | −2.98 | .022 | ||||
| Transmembrane receptors | |||||||||
| SELP | Selectin, platelet | −2.33 | .019 | ||||||
| SYT1 | Synaptotagmin 1 | −2.10 | .042 | ||||||
Bold fonts indicate genes differentially expressed both at 3 and 5 days.
Red fonts indicate the up‐regulated genes.
Blue fonts indicated the down‐regulated genes.