FIGURE 3.

Circ_0004712 directly suppresses the expression of miR‐148a‐3p. A, The target sites of circ_0004712 and miR‐148a‐3p. B, The expression of miR‐148a‐3p in E₂‐treated Ishikawa and End1/E6E7 cells was tested by qPCR. C, The expression of miR‐148a‐3p in E₂‐treated orE₂‐untreated Ishikawa and End1/E6E7 cells after for si‐circ or NC transfection was tested by qPCR. D, Relative luciferase activity in Ishikawa and End1/E6E7 cells transfected with miR‐NC or miR‐mimics and circ‐wild‐type (wt) or circ‐mutation (mut), respectively. Results show as mean ± SD. **Means compared with control group, P < 0.05. ##Means compared with E₂‐treated group, P < 0.05