FIGURE 4.

Computational analysis and luciferase assay showed a direct binding between miR‐145 and COL5A1 (*P value < .05. vs COL5A1 + miR‐145 NC group). A, Candidate seed sequences of miR‐145 in the 3′UTR of COL5A1 as detected by computational analysis; B, Luciferase activity of KNS‐89 cells transfected with wild‐type or mutant COL5A1 and miR‐145 mimics or miR‐145 negative controls; C, Luciferase activity of SNB‐19 cells transfected with wild‐type or mutant COL5A1 and miR‐145 mimics or miR‐145 negative controls