TABLE 1.
Definitions of variables of interest. (A) BMI categories; (B) SES; (C) Leukemia characteristics
| (A) | ||
|---|---|---|
| Pediatric (<20 y of age) (based on BMI for sex and age) | Adult (≥20 y of age) (BMI, kg/m2) | |
| Underweight | <5th percentile | <18.5 |
| Normal Weight | 5th‐<85th percentile | 18.5‐24.9 |
| Overweight | 85th‐<95th percentile | 25.0‐29.9 |
| Obesity | >95th percentile | >30.0 |
| (B) | ||
|---|---|---|
| Cases | Controls | |
| Low SES | >20% of the population in a ZIP code living at or below the federal poverty threshold | Poverty Income Ratio < 1.00 |
| High SES | <20% of the population in a ZIP code living at or below the federal poverty threshold | Poverty Income Ratio > 1.00 |
| (C) |
|---|
| ALL lineage (B‐ or T‐cell) |
| CNS status at diagnosis (CNS 1, 2, or 3) |
| CNS 1: Absence of leukemic blasts in CSF on cytospin preparation, regardless of WBC number |
|
CNS 2: Less than 5/uL WBCs in CSF and cytospin‐positive for blasts (or ≥5/uL WBCs but negative by Steinherz/Bleyer algorithm) |
|
CNS 3: At least 5/uL WBCs in CSF and cytospin‐positive for blasts and/or clinical signs of CNS leukemia |
| WBC count at diagnosis (<50 or >50 × 109/L) |
| Hypodiploidy (<44 chromosomes, DNA index <0.81) |
| BCR‐ABL1 fusion |
| ETV6‐RUNX1 translocation |
| KMT2A (MLL) rearrangement |
| Double Trisomy (Trisomies of chromosomes 4 and 10) |
Abbreviations: ALL, acute lymphoblastic leukemia; BMI, body mass index; CNS, central nervous system; CSF, cerebrospinal fluid; SES, socioeconomic status; WBC, white blood cell.