Figure 1.

Potential timepoints for tissue and liquid biopsy testing in HR+/HER2–ABC. ABC, advanced breast cancer; dMMR, mismatch repair deficient; HER2, human epidermal growth factor receptor 2; HR, hormone receptor; MSI‐H, microsatellite instability‐high; PE, physical examination; PIK3CA, phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha. ^†Otherbiomarkers:BRCA1/BRCA2, NTRK fusion, MSI‐H/dMMR. ^{30 ‡} therascreen ^® PIK3CA RGQ PCR Kit (tissue and plasma) and FoundationOne^® CDx(tissue). ⁴⁷ , ⁵⁵