TABLE 1.
Composite table of LGL leukemia and normal donor Original Cohort demographic and clinical information. All LGL leukemia patients chosen for this study had a confirmed diagnosis and were not on immunosuppressive treatment at the time of sample collection. The table lists data according to three groups: normal donors, NK‐LGL leukemia, and T‐LGL leukemia. STAT3 mutation status is listed for the LGL leukemia patients, with specific mutation breakdowns. Blood count data were available for n = 12 NK‐LGL leukemia and n = 33 T‐LGL leukemia patients. Blood count data were measured from the same research sample draw date, except one case where these were 6 wk apart. Five additional patients are missing blood count data due to these dates being too far apart from the research sample draw. The normal donors did not have blood count data, therefore, the normal reference ranges according to the University of Virginia clinical laboratory standards are listed. All parameters are reported as mean ± SD, with the range listed in parentheses
| Sample group | Normal donors | NK‐LGL leukemia | T‐LGL leukemia |
|---|---|---|---|
| n | 16 | 13 | 37 |
|
Mean age ± SD (Range) |
59.1 ± 12.9 (45‐79) |
62.5 ± 13.7 (32‐81) |
60.6 ± 14.6 (22‐88) |
| Sex | Female, n = 8 | Female, n = 5 | Female, n = 19 |
| Male, n = 8 | Male, n = 8 | Male, n = 18 | |
| STAT3 mutation status | Undetermined |
WT, n = 8 Mutated, n = 5 n = 1 S614R N647I K658R D661I D661Y |
WT, n = 21 Mutated, n = 16 n = 1 Y640F/Q643H Y640F/I659L Y640F/D661Y n = 2 N647I n = 4 Y640F n = 7 D661Y |
| WBC |
Reference range 4.00‐11.00 k/µL |
n = 12 8.96 ± 4.98 (2.24‐21.00) |
n = 33 9.63 ± 9.60 (1.05‐47.50) |
| Total lymphocytes |
Reference range 1.00‐5.00 k/µL |
n = 12 6.12 ± 5.03 (0.67‐19.10) |
n = 33 7.18 ± 8.87 (0.38‐43.70) |
| ANC |
Reference range 1800‐8000 cells/µL |
n = 12 2107 ± 909 (800‐4100) |
n = 33 1780 ± 1252 (180‐4940) |
| Hgb | Reference range |
Overall, n = 12 12.7 ± 1.3 (10.8‐15.2) |
Overall, n = 33 12.2 ± 2.3 (5.7‐15.9) |
| 12‐16 g/dL (F) |
Female, n = 5 12.4 ± 1.1 (11.0‐14.1) |
Female, n = 17 11.8 ± 2.1 (5.7‐14.1) |
|
| 14‐18 g/dL (M) |
Male, n = 7 12.8 ± 1.4 (10.8‐15.2) |
Male, n = 16 12.7 ± 2.5 (8.3‐15.9) |
|
| Hct | Reference range |
Overall, n = 12 37.7 ± 3.8 (32.4‐45.2) |
Overall, n = 33 36.3 ± 6.5 (16.6‐47.4) |
| 35.0%‐47.0% (F) |
Female, n = 5 36.7 ± 2.6 (34.1‐41.0) |
Female, n = 17 35.2 ± 6.2 (16.6‐43.0) |
|
| 40.0%‐52.0% (M) |
Male, n = 7 38.4 ± 4.5 (32.4‐45.2) |
Male, n = 16 37.5 ± 6.9 (25.8‐47.4) |
Abbreviations: ANC, absolute neutrophil count; Hct, hematocrit; Hgb, hemoglobin; LGL, large granular lymphocyte; NK, natural killer; WBC, white blood cell; WT, wild type.