Fig. 5.

Proposed mechanisms of food effect and their association with confidence in PBPK modeling for 30 modeled compounds. The inner layer of the plot depicts the confidence category, followed by direction of food effect in the second row, the BCS class in the third row, and the mechanism of food effect in the fourth row. The numbers in the first to third row indicate the number of compounds (out of 30) that fall in each category. More details around compound name and mechanism are provided in Table III