Table 2.

Parameter estimates of the final Multistate Tuberculosis Pharmacometric (MTP) model describing in vivo data

Parameter	Description	Estimate [RSE (%)]
		CFU only	CFU + MPN
Natural growth
${k_G}^a$ (days−1)	Growth rate of the fast multiplying state bacteria	0.804 (18)	2.62 (8)
${{k_{\mathit{FS}}}_{\mathit{Lin}}}^b$(days−2)	Second-order time dependent transfer rate between fast- and slow-multiplying state	0.253 (27)	0.316 (22)
$k_{\mathit{FN}}$ (days−1)	First-order transfer rate between fast- and non-multiplying state	0.749 × 10–3 (720)	1.75 (12)
$k_{\mathit{SN}}$ (days−1)	First-order transfer rate between slow- and non-multiplying state	0.206 (42)	0.183 (18)
$k_{\mathit{SF}}$ (days−1)	First-order transfer rate between slow- and fast-multiplying state	1.82 (65)	1.82 fix
$k_{\mathit{NS}}$ (days−1)	First-order transfer rate between non- and slow-multiplying state	1.5 × 10–2 (11)	0.49 × 10–2 (16)
F0c (mL−1)	Initial fast-multiplying state bacterial number	558 (139)	558 fix
S0c (mL−1)	Initial slow-multiplying state bacterial number	22,500 (20)	22,500 fix
ε (%)	Proportional residual error	34.6 (10)	36.9 (9)

Parameter values are presented as applied to colony forming unit (CFU) only and to CFU plus most probable number (MPN) dataRSE = relative standard error reported on the approximate standard deviation scale

^a$growth=F·k_G$

^b$k_{\mathit{FS}}={k_{\mathit{FS}}}_{\mathit{Lin}}$

^cFixed to value estimated from CFU observations alone

All final model codes (Supplemental Code. S3-S5) and datasets (Supplemental Datasets S6-S8) used for the model-development is included as supplementary information