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. 2020 Aug 29;19:8–18. doi: 10.1016/j.omto.2020.08.017

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© 2020.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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LV Suppressed HCC Development and Improved the Survival Rate in the Mouse Study

(A and B) The images of bioluminescence of HCC implanted in xenograft mice of Hep3B (A) or SNU-449 (B), from 0 to the 21st day of treatment, were displayed. (C and D) The bioluminescence value was significantly lower in the LV group compared to NC, at 14 and 21 days of treatment, in both Hep3B (C) and SNU-449 (D) cell line mice models. (E) The inhibition rates were calculated by comparing the biofluorescence signal of the LV group to that of NC. (F and G) LV also improved the survival rate of mice implanted with Hep3B (F) or SNU-449 (G) cells compared to NC groups. (H) Combined survival curve of both Hep3B and SNU-449 implanted mice. Data are presented as the mean ± SD; NS, not significant; NC, negative control.