FIGURE 6.

Effect of overnight incubation with different concentrations of benralizumab and mepolizumab on the cAMP concentrations in hyperresponsive bronchial tissue (a) and correlation between the cAMP concentrations and the modulation of myogenic tone to quick stretch (QS) induced by the investigated treatments (b). ^# P < 0.05 versus C−; *P < 0.05, versus C+ (statistical analysis assessed by the Student's t‐test); bars and points represent the mean ± SEM of n = 5 bronchial tissue from different subjects. The colours of bars in (a) and the relative treatments are consistent with the colours of points in (b). C+, positive control, passively sensitized bronchi; C−, negative control, non‐sensitized bronchi