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. 2020 Sep 9;177(20):4627–4644. doi: 10.1111/bph.15213

FIGURE 3.

FIGURE 3

Cholesterol efflux activity and cytotoxicity of the parent peptide apoA‐I221–240, P1–P17, and L‐4F in RAW264.7 cells. (a) Cholesterol efflux activity of apoA‐I mimetic peptides in RAW264.7 cells after 12 h of treatment. ApoA‐I221–240 and P1–P5 had no concentration‐dependent cholesterol efflux activities. P6–P17 and L‐4F had concentration‐dependent cholesterol efflux activities. (b) The cytotoxicity of apoA‐I mimetic peptides in RAW264.7 cells after 12 h of treatment. Over a concentration range from 0‐200μM, the parent peptide ApoA‐I221–240 and P1–P12 showed no cytotoxicity, whereas P13–P17 and L‐4F induced cytotoxicity. n = 5. Each experiment was repeated independently five times