TABLE 1.
Macroscopic and biochemical parameters in Klotho‐hypomorphic mice
| +/+ | kl/kl | |
|---|---|---|
| Macroscopic parameters | ||
| Body weight (BW, g) | 23.7 ± 0.3 (N = 22) | 8.4 ± 0.3* (N = 19) |
| Heart weight (HW, mg) | 169.0 ± 6.2 (N = 22) | 102.7 ± 5.3* (N = 19) |
| HW/BW ratio | 7.10 ± 0.20 (N = 22) | 12.37 ± 0.67* (N = 19) |
| Kidney weight (KW, mg) | 155.9 ± 4.4 (N = 22) | 58.1 ± 2.3* (N = 19) |
| Biochemical parameters | ||
| Urea (mg·L−1) | 357 ± 25 (N = 10) | 646 ± 49* (N = 10) |
| BUN (mg·L−1) | 167 ± 12 (N = 10) | 302 ± 23* (N = 10) |
| Phosphorus (mg·L−1) | 133. ± 7 (N = 10) | 1215 ± 8 (N = 10) |
| FGF‐23 (pg·ml−1) | 268.3 ± 36.7 (N = 10) | 457,318 ± 57,566* (N = 10) |
Note. Data for macroscopic and biochemical parameters per experimental group are reported as mean ± SEM. BUN, blood urea nitrogen; BW, body weight; FGF‐23, fibroblast growth factor 23; HW, heart weight; KW, kidney weight.
*
P < 0.05, significantly different from +/+ mice.