Table 3.
Quality of evidence and Grading of Recommendations Assessment Development and Evaluation (GRADE) recommendations for topical application of epidermal growth factor in different types of wounds
| Wound type | Quality of evidence | GRADE recommendation | References |
|---|---|---|---|
| Superficial partial-thickness burns | Moderate | Weak | 47–59 |
| Deep partial-thickness burns | Moderate | Weak | 47–62 |
| Donor sites | Moderate | Weak | 47–51 |
| Redisual granulation wounds after burns | Moderate | Weak | 48,50,51,53 |
| Diabetic foot ulcers | High | Strong | 47,63–70 |
| Venous ulcers | Moderate | Weak | 71–73 |
| CO2 laser treated wounds | Moderate | Weak | 74–76 |
| Grafted wounds | Low | Weak | 48 |
| Chronic ulcers after burns | Low | Weak | 48,53 |
| Radiative dermatitis wounds | Low | Weak | 77 |
| Leg ulcers | Low | Weak | 78 |