Table 6.

Application parameters of topical growth factors for skin wounds

Growth factor	Dosage form	Concentration	Common dose	Frequency	References
bFGF	Powder	Adjustable preparing solution	150 IU/cm2 or 1 μg/cm2	Once or twice per day	4–6,8,9,13,14,16,24,27
	Gel	2100 IU/g	150 IU/cm2	Once per day	96–99
aFGF	Powder	Adjustable preparing solution, e.g. 1000 IU/mL	100 IU/cm2	Once per day	42–43,45
EGF	Powder or solution	Adjustable preparing solution, e.g. 2000 IU/mL or 2.5 to 5.0 μg/mL or 10.0 μg/g	400 IU/cm2 or 80 mg/cm2	Once per day	21,100–103
	Gel or cream	10 μg/g or 20 to 40 μg/g	1 μg/cm2 or 50 000 IU/cm2 or 80 mg/cm2	Once every 1–4 days	60,67,104–107
GM-CSF	Powder	Adjustable preparing solution	5 μg/cm2	Once per day	108
	Gel	10 μg/g	1 μg/cm2 or 10 μg/cm2	Once per day	80–83,89
PDGF	Powder	Adjustable preparing solution, e.g. 100 μg/mL	10 μg/cm2	Once per day	93
	Gel	10 μg/g	10 μg/cm2	Once per day	90–92,94–95

bFGF basic fibroblast growth factor, aFGF acidic fibroblast growth factor, EGF epidermal growth factor, GM-CSF granulocyte macrophage colony stimulating growth factor, PDGF platelet-derived growth factor