Table 1.
Clinical and Biochemical Parameters of Study Subjects Categorized by Their Serum Cortisol Response to the Short Synacthen Test
| Variable | Normal (n=86) | AI (n=34) | P value |
|---|---|---|---|
| Age, yr | 58 (43–67) | 58 (42–67) | 0.650 |
| Female sex | 53 (61.6) | 17 (50) | 0.244 |
| BMI, kg/m2 | 23 (21–26) | 24 (22–27) | 0.188 |
| Serum albumin, g/dL | 4.3 (4.0–4.5) | 4.2 (3.9–4.4) | 0.257 |
| Serum creatinine, mg/dL | 0.7 (0.6–0.9) | 0.8 (0.6–1.0) | 0.786 |
| Estimated GFR, mL/min/1.73 m2 | 117 (95–134) | 113 (84–145) | 0.941 |
| Basal serum cortisol, nmol/L | 334 (239–454) | 80 (38–185) | <0.001 |
| Peak serum cortisol, nmol/L | 836 (674–940) | 352 (204–453) | <0.001 |
| Basal salivary cortisol, nmol/L | 6.18 (3.8–9.0) | 2.42 (1.23–3.75) | <0.001 |
| Peak salivary cortisol, nmol/L | 23.6 (16.8–34.4) | 5.73 (3.56–8.83) | <0.001 |
Values are expressed as median (interquartile range) or number (%).
AI, adrenal insufficiency; BMI, body mass index; GFR, glomerular filtration rate.