Table 2.
Molecular Features of TCGA THCA According to the LXRβ Expression Status
| Characteristic |
LXRβ expression |
P value | |
|---|---|---|---|
| Low expression (n=126) | High expression (n=126) | ||
| mRNA cluster number | <0.0001b | ||
| 1 | 49 (39.8) | 29 (24.2) | |
| 2 | 23 (18.7) | 6 (5.0) | |
| 3 | 17 (13.8) | 14 (11.7) | |
| 4 | 23 (18.7) | 31 (25.8) | |
| 5 | 11 (8.9) | 40 (33.3) | |
| miRNA cluster number | 0.161b | ||
| 1 | 5 (4.0) | 5 (4.0) | |
| 2 | 30 (24.2) | 35 (28.2) | |
| 3 | 15 (12.1) | 25 (20.2) | |
| 4 | 37 (29.8) | 27 (21.8) | |
| 5 | 17 (13.7) | 19 (15.3) | |
| 6 | 20 (16.1) | 13 (10.5) | |
| Ras mutation | 0.140b | ||
| Absent | 108 (87.1) | 115 (92.7) | |
| Present | 16 (12.9) | 9 (7.3) | |
| BRAF mutation | 0.572b | ||
| Absent | 70 (55.6) | 65 (52.0) | |
| Present | 56 (44.4) | 60 (48.0) | |
| TERT promoter mutation | 0.177b | ||
| Absent | 96 (91.4) | 75 (85.2) | |
| Present | 9 (8.6) | 13 (14.8) | |
| BRAF/RAS score | –0.10±0.77 | –0.36±0.65 | 0.014a |
| ERK score | 0.95±22.34 | 6.64±18.81 | 0.060a |
| Differentiation score | 0.35±1.18 | –0.25±1.04 | <0.0001a |
| Tumor status | 0.131b | ||
| Free | 98 (88.3) | 109 (94.0) | |
| With tumor | 13 (11.7) | 7 (6.0) | |
Values are expressed as number (%) or mean±standard deviation.
TCGA, The Cancer Genome Atlas; THCA, thyroid carcinoma; LXRβ, liver X receptor β; BRAF, B-Raf proto-oncogene; TERT, telomerase reverse transcriptase; RAS, RAS proto-oncogene GTPase; ERK, mitogen-activated protein kinase 1.
a
P values calculated by Student’s t test;
b
P values calculated by chisquare test or linear-by-linear association.