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. 2020 Sep 18;2020:5146982. doi: 10.1155/2020/5146982

Figure 2.

Figure 2

The lipid peroxidation index associated with ferroptosis was significantly altered in IIR-induced ALI. The mice were divided into four groups: sham, IIR, IIR+Fe, and IIR+Fer-1 after administrating Fe (15 mg/kg) and Fer-1 (5 mg/kg), respectively. (a) The level Nrf2 protein expression in each group was measured with a western blot and the representative quantification of Nrf2 protein (n = 6 per group). (b) The level of GPX4 in WT and Nrf2−/− group and the representative quantification of GPX4 protein (n = 6 per group). (c) The GSH level in the WT and Nrf2−/− group (n = 6 per group). (d) The MDA level in WT and Nrf2−/− group (n = 6 per group). (e) Representative TEM images of WT and Nrf2−/− mice. The white arrow indicates the ultrastructure of the mitochondria in the sham group, and the black arrows indicate the reduction or disappearance of mitochondrial cristae in the IIR group (n = 3 per group). ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, #P < .05, and ##P < .01 between the groups. ∗Compared with the sham group. #Compared with the IIR group.