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. 2020 Sep 18;2020:5146982. doi: 10.1155/2020/5146982

Figure 3.

Figure 3

pSTAT3 and the downstream protein, SLC7A11, were significantly increased in IIR-ALI and regulated by Nrf2. (a) The level of STAT3 mRNA in the Nrf2−/− mice compared with WT. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, #P < .05, and ##P < .01 between the groups. ∗Compared with the sham group; #Nrf2−/−compared with that of the WT group (n = 6 per group). (b) WT and Nrf2−/− mice were divided into four groups: sham, IIR, IIR+Fe, and IIR+Fer-1. The level of STAT3, pSTAT3, and SLC7A11protein expression was measured using a western blot. (c) The representative quantification of pSTAT3 protein, normalized to the corresponding level of total STAT3 (n = 6 per group). (d) The representative quantification of SLC7A11 protein, normalized to the corresponding level of β-actin (n = 6 per group). ∗P < .05, ∗∗P < .01, #P < .05, and ##P < .01 between the groups. ∗Compared with the sham group; #Nrf2−/−compared with that of the WT group.