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. 2020 Sep 18;2020:5146982. doi: 10.1155/2020/5146982

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Copyright © 2020 Zhuanzhuan Qiang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The activation of STAT3 in OGD/R-induced MLE12 ferroptosis was regulated by Nrf2. (a) Cells were transfected with Nrf2 interfering lentiviruses and then subjected to OGD/R. The level of GPX4, STAT3, and pSTAT3 expression was measured by western blot. ^∗P < .05, ^∗∗P < .01, ^∗∗∗P < .001, ^#P < .05, ^##P < .01, and ^###P < .001 between the groups. ^∗Compared with the control group; ^#shNC group compared with the shNrf2 group. (b) Cells overexpressing Nrf2 and then subjected to OGD/R. The level of GPX4, STAT3, and pSTAT3 was measured by western blot. ^∗P < .05, ^∗∗P < .01, ^∗∗∗P < .001, ^#P < .05, ^##P < .01, and ^###P < .001 between the groups. ^∗Compared with the control group; ^#shNC group compared with the shNrf2 group.