Table 4.

Critical appraisal of included SRs (short version)¹⁸

Quality criteria	Rashidian et al18	Neogi et al19	Lasswell et al20
1. Did the research questions and inclusion criteria for the review include the components of PICO?	NO	NO	YES
2. Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol?	Partial YES	NO	Partial YES
3. Did the review authors explain their selection of the study designs for inclusion in the review?	NO	NO	NO
4. Did the review authors use a comprehensive literature search strategy?	Partial YES	NO	Partial YES
5. Did the review authors perform study selection in duplicate?	YES	YES	NO
6. Did the review authors perform data extraction in duplicate?	YES	NO	YES
7. Did the review authors provide a list of excluded studies and justify the exclusions?	YES	NO	NO
8. Did the review authors describe the included studies in adequate detail?	YES	Partial YES	Partial YES
9. Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review?	Includes NRSI: YES	Not provided: NO	Includes NRSI and RCTs: NO
10. Did the review authors report on the sources of funding for the studies included in the review?	NO	NO	NO
11. Meta-analysis performed?	NO	NO	YES
(a) If meta-analysis was performed, did the review authors use appropriate methods for statistical combination of results for RCTs?	N/A	N/A	NO
(b) If meta-analysis was performed, did the review authors use appropriate methods for statistical combination of results for NRSI?	N/A	N/A	NO
12. If meta-analysis was performed, did the review authors assess the potential impact of RoB in individual studies on the results of the meta-analysis or other evidence synthesis?	N/A	N/A	YES
13. Did the review authors account for RoB in individual studies when interpreting/discussing the results of the review?	YES	NO	YES
14. Did the review authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the review?	N/A	N/A	YES
15. If they performed quantitative synthesis, did the review authors carry out an adequate investigation of publication bias (small study bias) and discuss its likely impact on the results of the review?	N/A	N/A	YES
16. Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review?	YES	YES	YES
Summary by authors: complete or partially fulfilled items (N=16 or 12, resp.)	9/12	3/12	11/16
Insufficient information in critical domains	1/7	5/7	3/7
Critical flaw* (insufficient information in item 9; insufficient information in items 1–4 and 7)	None	2	1
Overall confidence	Moderate	Critically low	Low

*Items written in italic are critical for an overall confidence rating.

N/A, not applicable; NRSI, non-randomised studies of interventions; PICO, Population, Intervention, Comparison, Outcome; RCT, randomised controlled trial; RoB, risk of bias; SRs, systematic reviews.