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. 2020 Sep 25;11:416. doi: 10.1186/s13287-020-01840-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Short LPS activation and TLR4 deletion impair the immunosuppressive capacity of MSCs in EAE mice. EAE mice were treated or not with MSCs WT, MSCs-TLR4KO, or MSCs pretreated with LPS for 1 h or 48 h. T lymphocytes derived from lymph nodes of EAE mice were analyzed by FACS at euthanasia. Representative dot plot of a Th17: CD4+IL17+, and Th1: CD4+IFNγ+ and b Tregs: CD4+CD25+FOXP3+ were analyzed. c Th17, d Th1, and e Treg total frequency were evaluated. *p < 0.05 (EAE control vs. LPS treated MSCs or MSCs-TLR4KO). δ p < 0.05, δδδ p < 0.001 (MSCs vs. LPS-treated MSCs or MSCs-TLR4KO). ^#p < 0.05 (LPS-treated MSCs vs. MSCs-TLR4KO). Statistics use was one-way ANOVA Kruskal-Wallis ad hoc post test