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. 2020 Sep 28;21:255. doi: 10.1186/s13059-020-02164-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Accessible transposable elements (TEs) in five mouse tissues. a Around 17~28% of ATAC-seq peaks identified in five mouse tissues associated with TEs, near half of these accessible TEs recruited H3K27ac signals. b Genomic distribution enrichment of accessible TEs of five mouse tissues in the mouse genome. Accessible TEs highly enriched in the exons of the mouse genome, especially the first exon. c Distribution of accessible TEs among five mouse tissues. Near half of accessible TEs were identified in only one tissue type. d Chromatin status of identified accessible TEs in mouse ES cells. In total, 65% of accessible TEs constitutively in five tissues were accessible in mouse ESC, only 10% of tissue-specific TEs were open in mESC. e Gene ontology (biological process) enrichment analysis of tissue-specific accessible TEs in five mouse tissues. GO terms related to tissue-specific function were selected to visualize. f TE class distribution of accessible TEs in five mouse tissues. g TE subfamily enrichment of accessible TEs in five mouse tissues