Skip to main content
. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Neuropharmacology. 2019 Dec 21;165:107831. doi: 10.1016/j.neuropharm.2019.107831

Figure 6. KOR activation did not affect synaptic transmission on GABA neurons in layer 5 of the IC.

Figure 6.

(A) vGATL10a reporter mice were used to identify GABA neurons in layer 5 of the IC for whole-cell recording. (B) In GABA neurons, 10 min bath application of dynorphin A (Dyn, 300 nM) did not alter the frequency or (C) amplitude of spontaneous excitatory postsynaptic current (sEPSC) from baseline (BL). (D) Representative traces of sEPSCs and (E) sIPSCs at baseline (black) and following Dyn (blue) wash-on. (F) There was no effect of Dyn on spontaneous inhibitory postsynaptic current (sIPSC) frequency, (G) amplitude, or (H) sEPSC/sIPSC (E/I) ratio in layer 5 IC GABA neurons. Females, open circles; males closed circles; n = 2–3 mice/sex; BL, baseline; Dyn, dynorphin A