Table 1. . Patient demographic and disease characteristics.
| Characteristic | Total (n = 44) | VTE (n = 18) | No VTE (n = 26) | CALGB 10403 [9] (n = 295) |
|---|---|---|---|---|
| Sex: – Females – Males |
16 (36.4) 28 (63.6) |
3 (16.7) 15 (83.3) |
13 (50) 13 (50) |
115 (39) 180 (61) |
| Age: – Median – Range – 18–20 – 21–29 – 30–38 |
23.5 18–38 13 (29.6) 17 (38.6) 14 (31.8) |
25 19–38 2 (11.1) 10 (55.6) 6 (33.3) |
22.5 18–37 11 (42.3) 7 (26.9) 8 (30.8) |
24 17–39 74 (25.1) 146 (49.5) 75 (25.4) |
| BMI kg/m2: – Median – Range – <30 – 30–40 – >40 |
24.5 18–48.2 36 (81.9) 2 (4.5) 6 (13.6) |
24 18.8–40.2 16 (89) 1 (5.5) 1 (5.5) |
25.4 18–48.2 20 (76.9) 1 (3.9) 5 (19.2) |
26.5 14.9–54.3 201 (68.1) 72 (24.4) 22 (7.5) |
| Race: – C – AA – Other – Unknown |
32 (72.7) 4 (9.1) 1 (2.3) 7 (15.9) |
14 (77.8) 0 0 4 (22.2) |
18 (69.2) 4 (15.4) 1 (3.9) 3 (11.5) |
220 (74.6) 29 (9.8) 19 (6.4) 27 (9.2) |
| Personal history of thrombosis: – Y – N |
1 (2.3) 43 (97.7) |
1 (5.6) 17 (94.4) |
0 26 (100) |
N/A N/A |
| Family history of thrombosis: – Y – N |
3 (6.8) 41 (93.2) |
2 (11.1) 16 (88.9) |
1 (3.9) 25 (96.1) |
N/A N/A |
| Smoking history: – Y – N |
16 (36.4) 28 (63.6) |
7 (38.9) 11 (61.1) |
9 (34.6) 17 (65.4) |
N/A N / A |
| On OCPs: – Y – N |
2 (4.5) 42 (95.5) |
1 (5.6) 17 (94.4) |
1 (3.9) 25 (26.1) |
N/A N/A |
| Cell subtype: – B – ALL – T – ALL – B – lymphoblastic lymphoma – T – lymphoblastic lymphoma |
28 (63.6) 12 (27.3) 1 (2.3) 3 (6.8) |
13 (72.2) 4 (22.2) 0 1 (5.6) |
15 (57.7) 8 (30.7) 1 (3.9) 2 (7.7) |
223 (75.9) 71 (24.1) 0 0 |
| WBC × 109/l at diagnosis: – Median – Range – ≤30 – >30 |
8.8 0.4–520 31 (70.5) 13 (29.5) |
5.3 0.71–82.6 16 (88.9) 2 (11.1) |
17.4 0.4–520 15 (57.7) 11 (42.3) |
9 0.4–444.6 217 (74.3) 75 (25.7) |
| Mediastinal mass at diagnosis: – Y – N |
8 (18.2) 36 (81.8) |
3 (16.7) 15 (83.3) |
5 (19.2) 21 (80.8) |
N/A N/A |
| Cytogenetics: – Unclassifiable – Intermediate – Unfavorable – Not fully evaluable – Favorable |
17 (38.6) 18 (40.9) 5 (11.4) 4 (9.1) 0 |
7 (38.9) 9 (50) 1 (5.6) 1 (5.6) 0 |
10 (38.5) 9 (34.6) 4 (15.4) 3 (11.5) 0 |
25 (9.8) 112 (43.6) 18 (7) 86 (33.5) 16 (6.2) |
N/A: Data were not evaluated in the CALGB 10403 population.
AA: African–American; ALL: Acute lymphoblastic leukemia; BMI: Body mass index; C: Caucasian; LBL: Lymphoblastic lymphoma; OCP: Oral contraceptive; WBC: White blood cell.