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Based on the findings from Figures 8 and 9, we summarized the proposed underlying mechanism of oxidative stress downstream signalling pathway participated in brain damage in setting of acute IS. Mel = melatonin; ROS = reactive oxygen species (ROS); ASK1 = apoptosis signal‐regulating kinase 1; MMK = mitogen‐activated protein kinase kinase; DRP1 = dynamin‐related protein 1
