Figure 4.

Inhibited XIAP reverses the effect of inhibited miR‐130a on neurological function and angiogenesis in rats with MCAO. A, Neurological function scores in each group; B, Spatial learning and memory function (latency and times of crossing the platforms) of rats in each group; C, Water content of brain tissue in each group; D, HE staining of brain tissues in each group (× 400); E, Comparisons of TTC staining and infarction ratio in the brain tissues in each group; F, Comparisons of TUNEL staining and the apoptotic index in the brain tissues in each group of rats (× 400); G, Expression of Caspase‐3, Bax and Bcl‐2 detected by Western blot analysis; H, Detection of proliferation and differentiation of endogenous NSCs in the brain tissues by double‐labelling immunofluorescence assay as well as its statistics analysis; I, Expression of neurotrophic factors (BDNF and NGF) in the brain tissues in each group; J, Evaluation of microvessel density in the brain infarction area by immunofluorescence staining; K, Expression of VEGF and HGF in the brain tissues in each group; ^# P < 0.05 vs the MCAO + miR‐130a inhibitors group. The results were expressed as mean ± standard deviation and comparisons among groups by one‐way ANOVA, followed by Tukey's post hoc test