Figure 4.

Exosomes derived from curcumin‐treated MSCs recovered the normal expression of ROCK1, TLR9 and NF‐kB proteins in cells treated with IL‐1β (*P < .05 vs control group, **P < .05 vs IL‐1β group). A, In primary chondrocytes treated with IL‐1β, the Western blot analysis showed abnormally increased expression of ROCK1, TLR9 and NF‐kB proteins, whose expression was suppressed by exosomes derived from curcumin‐treated MSCs. B‐D, Primary chondrocytes treated with IL‐1β displayed increased expression of ROCK1 (B), TLR9 (C) and NF‐kB (D) proteins, whose expression was dramatically inhibited by exosomes derived from curcumin‐treated MSCs