FIGURE 2.

P2X7R overexpression increases colorectal cancer tumour growth in vivo. A, CT26‐Con or CT26‐mP2X7R cells were orthotopically injected into the caecum subserosa of BALB/c mice, and the mice were killed after 6 weeks. The weight of tumours in the mice injected in the caecum with CT26‐Con or isolates of CT26‐mP2X7R cells (n = 10). B, Tumours from CT26‐Con and CT26‐mP2X7R mice. Scale bar: 5 mm. C, The expression of Ki67 in tumours from mice injected in the caecum with CT26‐Con and CT26‐mP2X7R cells was analysed by immunohistochemistry. Scale bar: 25 μm. D, The expression of cleaved caspase‐3 in tumours from mice injected in the caecum with CT26‐Con and CT26‐mP2X7R cells was analysed by immunohistochemistry. Scale bar: 25 μm