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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Pain. 2020 Sep;161(Suppl 1):S65–S86. doi: 10.1097/j.pain.0000000000001922

Figure 1: Mechanisms of glucotoxicity in diabetic neuropathy.

Figure 1:

Hyperglycemia has been considered central to the pathogenesis of diabetic neuropathy and multiple mechanisms have been proposed from both preclinical studies and clinical observations (see text for details).