Table 3. Relationship between molecular characteristics and alteration of m6A regulatory genes in patients with NSCLC.
Without mutation or CNV* | With mutation and CNV* | X2 | P | |||
EGFR | N=1017 | wt | 4 | 615 | 36.65 | <0.0001 |
alteration | 32 | 366 | ||||
ERBB2 | N=1017 | wt | 0 | 544 | 40.72 | <0.0001 |
alteration | 36 | 437 | ||||
ALK | N=1017 | wt | 0 | 459 | 28.84 | <0.0001 |
alteration | 36 | 522 | ||||
KRAS | N=1017 | wt | 5 | 547 | 22.87 | <0.0001 |
alteration | 31 | 434 | ||||
MET | N=1017 | wt | 2 | 573 | 37.36 | <0.0001 |
alteration | 34 | 408 | ||||
TP53 | N=1017 | wt | 1 | 672 | 64.11 | <0.0001 |
alteration | 35 | 309 |
*With mutation or CNV: Cases have mutant or CNV or mutant+CNV of m6A regulators, confirmed through TCGA database. Without mutant and CNV: Cases with neither mutant nor CNV of m6A regulators, confirmed through TCGA database.