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. 2020 Sep 11;12(17):17099–17113. doi: 10.18632/aging.103641

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Copyright: © 2020 Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Sirt6 deficiency leads to spermatogenic arrest at the elongated spermatid stage. (A) Paraffin-embedded sections of seminiferous tubules and testes from Sirt6^+/+ and Sirt6^-/- were stained with PAS-hematoxylin. B, B type spermatogonial stem cells; L, leptotene spermatocytes; D, diplotene spermatocytes; P, pachytene spermatocytes; rST, round spermatids; eST, elongated spermatids; M, meiotic divisions. 8-week mice, n=4. (B) Different developmental steps of single round spermatid and elongated spermatids from Sirt6^+/+ and Sirt6^-/- testes. 8-week mice, n=4. (C) Quantification of the proportion of round spermatids in the Sirt6^+/+ and Sirt6^-/- mice. Sirt6^+/+, 27.91±1.03%; Sirt6^-/-, 25.27±1.96%. 8-week mice, n=4; 96 seminiferous tubules were used for each group. (D) Quantification of the proportion of elongated spermatids in the Sirt6^+/+ and Sirt6^-/- mice. Sirt6^+/+, 26.67±0.48%; Sirt6^-/-, 2.64±0.12%. 8-week mice, n=4; 96 seminiferous tubules were used for each group. Data are presented as mean ± SEM. ***P < 0.001.