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. 2020 Sep 11;12(17):17099–17113. doi: 10.18632/aging.103641

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Copyright: © 2020 Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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SIRT6-deficiency leads to malformed spermatozoa with impaired acrosomes. (A) Immunofluorescence staining of PNA (green) and DAPI (blue) in Sirt6^+/+ and Sirt6^-/- spermatids. The acrosome is disrupted in Sirt6^-/- spermatids. (B) Quantification of intensity of elongated spermatids in (A). Sirt6^+/+, 33.84±0.90; Sirt6^-/-, 27.79±0.84, 8-week mice, n=4; 150 cells were used for each group. Data are presented as mean ± SEM. *P < 0.05. (C) Quantification of disrupted elongated spermatids of the Sirt6^+/+ and Sirt6^-/- mice. Sirt6^+/+, 4.22±0.57%; Sirt6^-/-, 91.16±1.08%, 8-week mice, n=4; 200 cells were used for each group. Data are presented as mean ± SEM. ***P < 0.001.