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. 2020 Sep 13;12(17):17436–17458. doi: 10.18632/aging.103750

Figure 4.

Figure 4

JMT inhibited APP expression and promoted serum NRG1 level in DPN rats. (A) Representative images of longitudinal sections of sciatic nerves with immunolabeling for APP (green), βIII-tubulin (red), and DAPI (blue, marking nuclei) at a magnification of 400×; scale bars, 20 μm. (B) Percentage of APP+ axonal area with βIII-tubulin colocalization. (C) Panels of serum NRG1 level in different groups. Means ± SD; n=3-8/group. ****p < 0.0001, **p < 0.01 vs. normal control group; ††p < 0.01, †p < 0.05 vs. distilled water-treated DPN group. One-way ANOVA followed by Tukey’s multiple comparison test.