Figure 3.

Model for noise reduction in PCR by helicase. Image of noise reduction in PCR by helicase such as a Tk-EshA is shown in the figure. In the absence of helicase, primers mis-anneal to various homologous regions, resulting in the amplification of noise DNAs. In the presence of helicase shown as a pacman, mis-annealed primers are peeled off and specific primers dominantly anneal to the target region, resulting in the reduced amplification of noise DNAs.