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. 2020 Sep 21;46(5):1644–1652. doi: 10.3892/ijmm.2020.4734

Figure 2.

Figure 2

In osteosarcoma, CAPN6 involves related signal pathways. CAPN6 is a downstream molecule of EDN-1 signaling. EDN-1 can induce the continuous activation of NF-κB, ERK1/2 and AKT pathways, and promote the expression of CAPN6 in osteosarcoma. Syndecan-2 is a key regulator of cell death. Overexpression of syndecan-2 in osteosarcoma cells can decrease the levels of CAPN6 in the tumor cells, and can alter EDN-1 signaling. PI3K/AKT and NF-κB are new pathways controlled during their pro-apoptotic process. In cells with syndecan-2 overexpression, steady-state activation of ERK1/2 and AKT is low. Therefore, syndecan-2 can inhibit EDN-1 signal transduction, and down-regulate CAPN6 expression through ERK1/2, PI3K/AKT and NFκB pathways to exert its function to promote apoptosis. CAPN6, calpain6; EDN-1, endothelin-1; NF-κB, nuclear factor-κ-gene binding; ERK1/2, extracellular regulated protein kinase 1/2; AKT, protein kinase B.