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. 2020 Sep 15;46(5):1683–1694. doi: 10.3892/ijmm.2020.4727

Figure 6.

Figure 6

Effects of ARID1A on the cell cycle, apoptosis, and the expression of angiogenesis-related proteins and mRNAs. (A and B) Detection of the protein expression of ARID1A, VEGF, cyclin D1, Bcl-2 and Bax in MCF7 cells by WB analysis. (C) Detection of the mRNA expressions of ARID1A, VEGF, cyclin D1, Bcl-2 and Bax in MCF7 cells by RT-qPCR. (D and E) Detection of the protein expression of ARID1A, VEGF, cyclin D1, Bcl-2 and Bax in MDA-MB-231 cells by WB analysis. (F) Detection of the mRNA expression of ARID1A, VEGF, cyclin D1, Bcl-2 and Bax in MDA-MB-231 cells by RT-qPCR. Data were obtained from 3 representative experiments and are presented as the means ± standard deviation. The experiment was repeated 3 times (n=3). **P<0.001 vs. siNC or NC; ##P<0.001 vs. siARID1A or ARID1A; ^P<0.05, ^^P<0.001 vs. siNC + 5-FU or NC + 5-FU. ARID1A, AT-rich interactive domain 1A; 5-FU, 5-fluorouracil; WB analysis, western blot analysis.