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. 2020 Aug 25;46(5):1794–1804. doi: 10.3892/ijmm.2020.4710

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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KCNQ1OT1 knockdown enhanced sorafenib sensitivity, promoted cell apoptosis, and inhibited cell migration and invasion by targeting miR-506 in sorafenib-resistant HCC cells. sh-KCNQ1OT1, sh-NC, sh-KCNQ1OT1+anti-miR-506 or sh-KCNQ1OT1+anti-NC was transfected into SK-HEP-1/sorafenib and Huh-7/sorafenib cells. (A and B) The sorafenib resistance of SK-HEP-1/sorafenib and Huh-7/sorafenib cells was assessed by Cell Counting Kit-8 assay. (C and D) The apoptosis of SK-HEP-1/sorafenib and Huh-7/sorafenib cells was evaluated by flow cytometry. (E-H) The migration and invasion of SK-HEP-1/sorafenib and Huh-7/sorafenib cells were determined by Transwell assay. ^*P<0.05. HCC, hepatocellular carcinoma; KCNQ1OT1, KCNQ1 overlapping transcript 1. Scale bar, 100 μm.